br For systemic cancerous disease cachexia is the
For systemic cancerous disease, cachexia is the cause of death. Most cancer patients do not die of tumor, but of cancer cachexia. Eradicating tumor cell cannot cure systemic cancerous disease; on the contrary, the poiso-nous side eﬀect of therapies usually speeds up the progress of CC and death. It is important for curing cancer cachexia and restoring the patient's constitution to prevent systemic cancer and improve the quality of life and prolong the survival.
Cancer is related to natural physical, chemical, and biological fac-tors, as well as negative emotion. Almost all cancer patients have symptoms of anorexia, fatigue, and emaciation. Cancer related fatigue (CRF) is a kind of physical and psychological fatigue. CRF is painful experience of cancer patients. The causes of CRF are believed to be tumor, abnormality of muscle energy metabolism, parahypnosis, physiological rhythm anomaly, inflammation, stress,
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dysimmunity, and anomaly of hypothalamus pituitary axis hormone [1,2].
The significant feature of Cancer cachexia (CC) is progressive re-duction of skeletal muscle. CC makes the patient skeletonization. CC is diﬀerent from starvation. Starvation mainly reduces body fat, but CC mainly reduces skeletal muscle. Nutritional therapy cannot reverse CC.
CC severely impact the quality of life and shorten the survival. Most cancer patients do not die of tumor but of CC ultimately. The therapies treating tumor usually speed up the progress of CC and death. CC is
believed to be a primary, tumor-activated autoimmune chronic in-flammatory response, and IL-6, IL-10, IL-8, TNFα, as well as other in-flammatory factors play central role in CC [3,4].
Does cancer start as a small tumor and later spread, or is cancer a systemic disease with tumors only late stage symptoms, or a mixture of these. Dose tumor leads to CC, or does CC facilitate tumor development. There is no mode to explain the relationship among tumor and CRF and CC by now.
The aim of this study is to research the causes of tumor, CRF and CC, and the relationship among tumor and CRF and CC.
The cause of tumor
Carcinogenesis is consequence of failure of tissue development. Tumor originates from tissue regeneration. Tumor cell is normal in-complete diﬀerentiated cell that stops in diﬀerent phases of diﬀer-entiation. Tumor promoter stimulates stem 11024-24-1 to proliferate. Carcinogen obstructs stem cells to diﬀerentiate. With tumor promoter and carcinogen, the tissue stem cell proliferates but cannot diﬀerentiate into mature cell, and forms tumor . The disorder of biological signals of cell proliferation and diﬀerentiation facilitates tumor development.
The cause of cancer related fatigue and cancer cachexia
Fatigue and cachexia are common in cancer patients, but fatigue and cachexia also appear in aged people and other diseases. CRF and CC are consequence of endocrine hypofunction and failure caused by per-sistent stress.
Stress is primary non-specific physiological response to various sti-muli. Stress helps body to coordinate organic function to cope with internal and external changes. Nature factors and psychological factors all can stimulate organic stress. The significant feature of stress is the activation of hypothalamic pituitary adrenal axis. Proper stress helps organism to overcome pathogens and recover quickly. The intense or/ and persistent stress would exhaust the capacity of the endocrine glands or hormone receptors of target cells, and leads to endocrine failure and unbalance of homeostasis.
(1) Hypoadrenocorticism makes patient debility, fatigue, inappetence, emaciation, nausea, emesis, celialgia, diarrhea, hypotension, diz-ziness and so on.
(2) Hypothyroidism makes patient chill, somnolence, slow response, rough skin and so on.
(3) Hypogonadism makes patient sexual hypoactivity, erectile dys-function (ED), menstrual disorder.
Most cancer patients have the symptoms of debility, fatigue, in-appetence, emaciation, nausea, emesis, celialgia, diarrhea, hypoten-sion, dizziness, chill, somnolence, slow response, rough skin, sexual hypoactivity, erectile dysfunction (ED), and menstrual disorder. Those symptoms are consistent with that of hypoadrenocorticism, hypothyr-oidism and hypogonadism. CRF and CC are clinical manifestation of endocrine hypofunction and failure.
The relationship among tumor and cancer related fatigue and cancer cachexia
Cancer is a local lesion, also is a systemic disease. As a local lesion, carcinogen obstructed stem cell to diﬀerentiate, developmental failure of local tissue forms tumor. As a systemic disease, cancer is related to natural physical, chemical, and biological factors, as well as negative