br Conclusion br The aim of this study
The aim of this study was to develop an eﬃcient strategy for con-current delivery of heat and drug to the tumor by taking the advantages of nanotechnology in order to achieve synergistic therapeutic out-comes. Aside from the improved chemotherapy eﬃcacy than free drug
M. Mirrahimi, et al.
administration and the good light-to-heat conversion property, the nanocomplex developed herein in combination with 532 nm laser ir-radiation dramatically inhibited tumor growth and eﬃciently removed microscopic residual tumor. This nanocomplex could potentially reduce the adverse side eﬀects regarding the use of conventional thermo-che-motherapy, improve the quality of life of cancer patients, and even-tually giving the promise to raise the chance of cancer cure.
Conflict of interest
Non to be declared.
All supports received from IUMS and ZaUMS are acknowledged. The authors also express their gratitude to the TUMS Pre-Clinical Core Facilities (TPCF), Tehran, Iran, for providing animal imaging and image processing services for this study.
H. Ghaznavi, A. Shakeri-Zadeh, Selective heat generation in cancer Mocetinostat (MGCD0103, MG0103) using a combination of 808 nm laser irradiation and the folate-conjugated [email protected] Au nanocomplex, Artif. Cells Nanomed. Biotechnol. 46 (2018) 241–253.
H. Ghaznavi, F. Faeghi, Real-time mapping of heat generation and distribution in a laser irradiated agar phantom loaded with gold nanoparticles using MR tempera-ture imaging, Photodiagnosis Photodyn. Ther. 25 (2019) 66–73.  O. Dahl, Interaction of heat and drugs in vitro and in vivo, Thermoradiotherapy and Thermochemotherapy, Springer, 1995, pp. 103–121.
A. Mahmoudabadi, H. Ghaznavi, A. Shakeri-Zadeh, The benefits of folic acid-modified gold nanoparticles in CT-based molecular imaging: radiation dose re-duction and image contrast enhancement, Artif. Cells Nanomed. Biotechnol. 46 (2018) 1993–2001.
H. Ghadiri, A nanotechnology-based strategy to increase the eﬃciency of Cancer diagnosis and therapy: folate-conjugated gold nanoparticles, Curr. Med. Chem. 24 (39) (2017) 4399–4416.
M.S. Ghasemi, M.B. Shiran, Measurements of nanoparticle-enhanced heating from 1 MHz ultrasound in solution and in mice bearing CT26 colon tumors, J. Therm. Biol. 62 (2016) 84–89.
S.K. Kamrava, Gold-coated magnetic nanoparticle as a nanotheranostic agent for magnetic resonance imaging and photothermal therapy of cancer, Lasers Med. Sci. 32 (7) (2017) 1469–1477.
 A. Shakeri-Zadeh, H. Eshghi, G. Mansoori, A. Hashemian, Gold nanoparticles con-jugated with folic acid using mercaptohexanol as the linker, J. Nanotechnol. Progress Int. 1 (2009) 13–23.  H. Ghaznavi, S. Hosseini-Nami, S.K. Kamrava, R. Irajirad, S. Maleki, A. Shakeri-Zadeh, A. Montazerabadi, Folic acid conjugated PEG coated gold–iron oxide core–shell nanocomplex as a potential agent for targeted photothermal therapy of cancer, Artif. Cells Nanomed. Biotechnol. 46 (8) (2018) 1594–1604.
 A. Hashemian, H. Eshghi, G. Mansoori, A. Shakeri-Zadeh, A. Mehdizadeh, Folate-conjugated gold nanoparticles (synthesis, characterization and design for cancer cells nanotechnology-based targeting), Int. J. Nanosci. Nanotechnol. 5 (1) (2009) 25–34.
A. Shakeri-Zadeh, Folate-modified and curcumin-loaded dendritic magnetite na-nocarriers for the targeted thermo-chemotherapy of cancer cells, Artif. Cells Nanomed. Biotechnol. 47 (2019) 330–340.
 Z. Alamzadeh, J. Beik, V.P. Mahabadi, A.A. Ardakani, A. Ghader, S.K. Kamrava, A.S. Dezfuli, H. Ghaznavi, A. Shakeri-Zadeh, Ultrastructural and optical char-acteristics of cancer cells treated by a nanotechnology based chemo-photothermal therapy method, J. Photochem. Photobiol. B, Biol 192 (2019) 19–25.